Laurent Metzinger, University of Picardie Jules Verne, France
Non-coding RNAs were discovered at the turn of the 21th century. Several families exist, including long non-coding RNAs, and short non -coding RNAs. The importance of these various RNA species are just beginning to be understood in the nephrology field, and related cardiovascular [....] » Read More
Title : Resveratrol derivatives a new tool for osteogenic induction in the treatment of peri implantitis
Barbara De Filippis, University “G. d’Annunzio, Italy
Dental implants offer a reliable therapeutic option for tooth replacement therapy. However, the early and late failures are still a major concern of clinicians. Peri-implant tissues contribute to ensuring healthy conditions, stable osseointegration, and long-term survival because [....] » Read More
Title : miR-29b inhibition in triple negative cells target apoptosis and autophagy related mechanisms
Cornelia Braicu, Iuliu Haţieganu University of Medicine and Pharmacy, Romania
Introduction: The lack of receptors in triple-negative breast cancer (TNBC) restricts therapeutic alternatives options that can be used for clinical management. microRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate gene expression. miR-29b w [....] » Read More
Title : Mucoadhesive microcapsule: A novel approach for controlling & sustained drug delivery!
Subas Chandra Dinda, Teerthanker Mahaveer University, India
Statement of the Problem: Problems associated with poor bioavailability through oral route and administration difficulties through injectable routes promoted the impetus for exploring alternative routes for the delivery of such drugs. Application of dosage forms through mucosal s [....] » Read More
Title : Innate Immune memory based therapeutics in the resolution of inflammation
Liwu Li, Virginia Polytechnic Institute and State University, United States
Emerging studies suggest a novel role of innate immune memory during the pathogenesis and treatment of diverse inflammatory diseases. However, the fundamental principles that underlie the generation of innate immune memory are not well understood, thus hindering the effective dev [....] » Read More
Title : Targeting breast cancer through prodrug activation by cytochrome P450 1A1
Sebastien Fortin, Laval University, Canada
Human cytochromes P450 (CYPs) constitute a large superfamily of monooxygenase enzymes that catalyze over 40 different redox reactions. They are ubiquitous and are the main enzymes involved in drug biotransformation. CYPs also metabolize a considerable number of structurally diffe [....] » Read More
Title : Introducing Novel Hybridization Technique for Solubility Enhancement of Bosentan Formulation
Chetna Dipak Modi, Anand Pharmacy College, India
Bosentan is one of 40% NCEs developed in Pharma-Industry which are practically insoluble in water & choice of drug for pulmonary arterial hypertension. Due to poor solubility in aqueous media, treatment leads to frequent dosing & increasing cost of therapy subsequently. O [....] » Read More
Title : Formulation Development and Characterization of Novel Nano formulation to Enhance Bioavailability by Using Quality by Design Approach
Neha Bajwa, Maharaja Ranjit Singh Punjab Technical University, India
Background : Malaria is endemic in over 90 countries in which 2400 million people live (WHO, 2017). With the emergence of widespread chloroquine resistance and worldwide scarcity of quininine, search for newer antimalarial drugs has become imperative (Chadda et al., 2011). [....] » Read More
Title : Solid dispersion approach for solubility enhancement of Arteether employing hydrophilic carriers
Shagun Katoch, Maharaja Ranjit Singh Punjab Technical University, India
Arteether (AE), an ethyl ether derivative of dihydroartemisinin, is one of the most extensively utilized medicaments in treating drug-resistant malaria globally. It is a BCS class II drug with low solubility (≅17μg/mL), limited dissolution rate, and oral bioavailabil [....] » Read More
Title : Quality by Design based Development and Characterization of Patient Compliant Dosage form for Pediatrics
Srishti Naryal, Maharaja Ranjit Singh Punjab Technical University, India
The development of pediatric dosage forms can be challenging due to administration route, strength, and toxicity issues. In addition, children do not well receive the conventional pediatric formulations for various reasons, including choking due to larger size, vomiting due [....] » Read More
Title : Development, Optimization, and Characterization of Golden Milk as Immunobooster in Covid-19 using Qbd Approach
Pallvi Saroch, Maharaja Ranjt Singh Punjab Technical University, India
In the wake of the COVID-19 outbreak, enhancing the body’s immunity plays an important role in maintaining optimum health. Turmeric in milk generally known as golden milk is recommended to consume for boosting immunity. In the present study, turmeric milk powder was prepare [....] » Read More
Title : Quality by Design approach based Development of Arteether loaded Solid Lipid Nanoparticles
Trisha Sharma, Maharaja Ranjt Singh Punjab Technical University, India
Malaria is a severe endemic disease that affects 5% of the population across the globe. In 2018, there were 198 million cases of malaria, which resulted in 5,84,000 fatalities. The majority of these instances (90%) occurred in children under the age [....] » Read More
Title : Development of Flavoured Oral Disintegrating Mini Tablets by Using Quality by Design Approach
Shipra Mahal, Maharaja Ranjt Singh Punjab Technical University, India
Designing a pediatric formulation is a challenge due to palatability, administration issues and also requires a thorough understanding of developmental physiological changes, specific dose requirements according to child's body surface area, age as well as toxi [....] » Read More
Title : Studies on formulation and evaluation of orally disintegrating tablets using musa acuminata as a natural disintegrant for paediatric use
Ashwini V Jadhav, Genba Sopanrao Moze College of Pharmacy, India
The aim of the present study was to optimize an orally disintegrating tablet of ibuprofen (~100mg) using Musa acuminata (dehydrated banana powder) as a natural super disintegrant. In this work dehydrated banana powder was used as pharmaceutical excipient because of natural [....] » Read More
Title : Nutraceuticals in the prevention and treatment of Covid-19
Richard Cheng, Cheng Integrative Health Center, United States
Over a short 2+ years of the Covid-19 pandemic, SARS-Cov-2 virus has undergone numerous mutations with several major global outbreaks such as the delta and omicron variants. Covid-19 is not over yet, monkeypox is now lurking at the corner. Global responses to Covid-19 include soc [....] » Read More
Title : Cost effectiveness of antineoplastic agents preparations for personalized cancer therapy in the UHC “Mother Theresa” Tirana
Florjana Rustemi, Albanian University, Albania
This study determines the cost effectiveness of personalized cancer therapy based on the reduction of costs for each treatment cycle for the drug Bortezomib using antineoplastic agents’ preparation in the bio-safety cabinet of the Hematology pharmacy of the UHC “Mothe [....] » Read More
Title : Novel Spiro Hybrids of 2-indolinone and Thiazolodinone Scaffolds as Cell Cycle Checkpoints’ Pathways Regulators with potential anticancer activity
Tarek Aboul Fadl, Assuit University, Egypt
In recent years, cell cycle and checkpoint pathways regulation are offering new therapeutic approaches against cancer. 2-Indolinone, is a well exploited scaffold in the anticancer domain. Accordingly and in continuation of our previous studies, the current work describes merged s [....] » Read More
Title : In Vitro And Ex-Vivo Evaluation Of Curcumin Loaded Olive Oil/Beeswax Oleogels
Ahmet Dogan Ergin, Trakya University/Faculty of Pharmacy, Turkey
Oleogels are organic gels that are prepared by adding an organogelator agent to a liquid oil that will gel it, turn into solid/semi-solid form at room temperature, mostly consisting of thermoreversible three-dimensional network structures. It is a newly developed technology in re [....] » Read More