Title : Resveratrol derivatives a new tool for osteogenic induction in the treatment of peri implantitis
Barbara De Filippis, University “G. d’Annunzio, Italy
Dental implants offer a reliable therapeutic option for tooth replacement therapy. However, the early and late failures are still a major concern of clinicians. Peri-implant tissues contribute to ensuring healthy conditions, stable osseointegration, and long-term survival because [....] » Read More
Title : Innate Immune memory based therapeutics in the resolution of inflammation
Liwu Li, Virginia Polytechnic Institute and State University, United States
Emerging studies suggest a novel role of innate immune memory during the pathogenesis and treatment of diverse inflammatory diseases. However, the fundamental principles that underlie the generation of innate immune memory are not well understood, thus hindering the effective dev [....] » Read More
Title : Drugs as an environmental problem chromatographic and computational studies of drugs partition between soil and water
Anna Weronika Sobanska, Medical University of Lodz, Poland
The fate and transport of solutes in the environment depend on their physico-chemical properties such as lipophilicity, volatility, water solubility and ability to partition between soil and water. The soil-water partition coefficient Koc (normalized to the soil organic carbon co [....] » Read More
Title : Comparative Study on Inhibition of Pancreatic Cancer Cells by Resveratrol Gold Nanoparticle and Resveratrol Nanoemulsion Prepared from Grape Skin
Bing Huei Chen, Fu Jen Catholic University, Taiwan
Resveratrol, a phenolic compound possessing vital biological activities such as anti-cancer, is present abundantly in grape skin, a waste produced during processing of grape juice. The objectives of this study were to prepared resveratrol-gold nanoparticle and resveratrol nanoemu [....] » Read More
Title : Non-coding RNAs in the cardiovascular disorders linked to Chronic Kidney Disease
Laurent Metzinger, University of Picardie Jules Verne, France
Non-coding RNAs were discovered at the turn of the 21th century. Several families exist, including long non-coding RNAs, and short non -coding RNAs. The importance of these various RNA species are just beginning to be understood in the nephrology field, and related cardiovascular [....] » Read More
Title : Adiposome a Hydrophobic Drug Delivery System
Pingsheng Liu, Chinese Academy of Sciences, China
Liposome is a good drug delivery system for hydrophilic molecules. For delivery of hydrophobic molecules, a new system has to be developed. To mimic lipoproteins and lipid droplets, we generated sphere-shaped structures with a neutral lipid core and a monolayer phospholipid membr [....] » Read More
Title : Targeting breast cancer through prodrug activation by cytochrome P450 1A1
Sebastien Fortin, Laval University, Canada
Human cytochromes P450 (CYPs) constitute a large superfamily of monooxygenase enzymes that catalyze over 40 different redox reactions. They are ubiquitous and are the main enzymes involved in drug biotransformation. CYPs also metabolize a considerable number of structurally diffe [....] » Read More
Title : Introducing Novel Hybridization Technique for Solubility Enhancement of Bosentan Formulation
Chetna Dipak Modi, Saraswati Institute of Pharmaceutical Sciences, India
Bosentan is one of 40% NCEs developed in Pharma-Industry which are practically insoluble in water & choice of drug for pulmonary arterial hypertension. Due to poor solubility in aqueous media, treatment leads to frequent dosing & increasing cost of therapy subsequently. O [....] » Read More
Title : Liposphere loaded floating raft system as a novel liquid gastroretentive drug delivery system development in vitro characterization and in vivo assessment
Baher Daihom, Cairo University, Egypt
This work aims to develop a novel liposphere-loaded floating raft system (FRS) as a liquid gastroretentive drug delivery system (GRDDS), employing lipospheres to sustain the drug release from the highly porous alginate-based raft system without hindering its buoyancy. Different t [....] » Read More
Title : Development of Flavoured Oral Disintegrating Mini Tablets by Using Quality by Design Approach
Shipra Mahal, Maharaja Ranjt Singh Punjab Technical University, India
Designing a pediatric formulation is a challenge due to palatability, administration issues and also requires a thorough understanding of developmental physiological changes, specific dose requirements according to child's body surface area, age as well as toxi [....] » Read More
Title : Quality by Design approach based Development of Arteether loaded Solid Lipid Nanoparticles
Trisha Sharma, Maharaja Ranjt Singh Punjab Technical University, India
Malaria is a severe endemic disease that affects 5% of the population across the globe. In 2018, there were 198 million cases of malaria, which resulted in 5,84,000 fatalities. The majority of these instances (90%) occurred in children under the age [....] » Read More
Title : Quality by Design based Development and Characterization of Patient Compliant Dosage form for Pediatrics
Srishti Naryal, Maharaja Ranjit Singh Punjab Technical University, India
The development of pediatric dosage forms can be challenging due to administration route, strength, and toxicity issues. In addition, children do not well receive the conventional pediatric formulations for various reasons, including choking due to larger size, vomiting due [....] » Read More
Title : Development, Optimization, and Characterization of Golden Milk as Immunobooster in Covid-19 using Qbd Approach
Pallvi Saroch, Maharaja Ranjt Singh Punjab Technical University, India
In the wake of the COVID-19 outbreak, enhancing the body’s immunity plays an important role in maintaining optimum health. Turmeric in milk generally known as golden milk is recommended to consume for boosting immunity. In the present study, turmeric milk powder was prepare [....] » Read More
Title : Emulgel: A Potential Tool for Topical Drug Delivery System
Smita More, Savitribai Phule Pune University, India
Emulgel as a topical drug delivery system which is an emerging field if given more efforts in its formulation and development it will turn out as a boon for topical delivery of drugs. Emulgels are oil-in-water or water-in-oil emulsions gelled by using gelling agents. Gels have so [....] » Read More
Title : Advanced multifunctional carbon-based nanomedecides for cancer therapy
Gil Goncalves, University of Aveiro, Portugal
Carbon-based nanomaterials have led to exciting new challenges in the design of smart materials capable of addressing a wide range of social challenges. New synthetic strategies have been extensively investigated for the development of advanced functional carbon nanomaterials, sh [....] » Read More
Title : Pharmacopollution and Household Waste Medicine (HWM): an applied view
Andre Luiz Pereira, Fundacao Hemominas, Brazil
Pharmacopollution is a public health and environ-mental outcome of some active pharmaceutical ingredients(API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are thep harmaceutical industry, healthcare facilities (e.g., ho [....] » Read More