Non-coding RNAs were discovered at the turn of the 21th century. Several families exist, including long non-coding RNAs, and short non -coding RNAs. The importance of these various RNA species are just beginning to be understood in the nephrology field, and related cardiovascular [....] » Read More
The fate and transport of solutes in the environment depend on their physico-chemical properties such as lipophilicity, volatility, water solubility and ability to partition between soil and water. The soil-water partition coefficient Koc (normalized to the soil organic carbon co [....] » Read More
To discuss the reports on various antiproliferative Heterocyclic Scaffolds (APHSs) produced by different reaction protocol such as optimization conditions, importance of catalyst, routes for the diverse synthesis etc. The antiproliferative assay will be explore for all synthesize [....] » Read More
Drug repurposing may be defined as developing old drugs for new indications. These old drugs may include already commercialized products, and drugs in clinical development. Drug repurposing approach is very cost-effective in putting new drugs in market, especially for rare diseas [....] » Read More
Emulgel as a topical drug delivery system which is an emerging field if given more efforts in its formulation and development it will turn out as a boon for topical delivery of drugs. Emulgels are oil-in-water or water-in-oil emulsions gelled by using gelling agents. Gels have so [....] » Read More
Coronaviruses are a family of viruses that can cause illnesses such as the common cold, Fever, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), Cancer, Asthma etc.Respiratory infection (RTI) is a viral spreading disease and it transmits from indi [....] » Read More
Background: Since, ancient times various ayurvedic drugs have been widely explored for their therapeutic potencies. Aim: Among the various crude drugs, Curcuma longa is one of the most important medicinal plant. It exhibits various useful pharmacological properties and used in [....] » Read More
Medicinal plants have emerged an important source in governing healthy condition and minimizing the side effects of modern- day medicine. Many evidence-based reports are paved in the literature about the numerous beneficial aspects of medicinal plants. Clitoria ternatea L. belong [....] » Read More
The pharmacokinetics (PK) of a drug is important as it dictates the pharmacological activity and therapeutic response. When it comes to paediatric population, a number of anatomical and physiological factors determine the pharmacokinetic profile of a drug and thereby becomes a ch [....] » Read More
Pharmaceuticals are indispensable and an integral part of our daily lives and are used for our well being yet the extensive and uncontrolled usage under different classes such as antibiotics, analgesics, antipyretics, antidepressant, anticonvulsants, beta-blockers, steroids, anti [....] » Read More
In these COVID-19 times, the final medication for this pandemic is yet on its way and in the meantime NO-based drugs are under clinical trials for the use in COVID-19 treatment. The rationale is based on the expression of NO in an infected area by pathogen as well as by humans by [....] » Read More
Carbon-based nanomaterials have led to exciting new challenges in the design of smart materials capable of addressing a wide range of social challenges. New synthetic strategies have been extensively investigated for the development of advanced functional carbon nanomaterials, sh [....] » Read More
Pharmacopollution is a public health and environ-mental outcome of some active pharmaceutical ingredients(API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are thep harmaceutical industry, healthcare facilities (e.g., ho [....] » Read More
Introduction: Cannabis has recently gained a medical status in several countries in the world. Its production for medical purposes should be analysed based on the three pillars of sustainability, taking into account the country in which it is located. Methods: literary researc [....] » Read More
Invasive pulmonary aspergillosis (IPA) is a major cause of morbidity and mortality in immunocompromised patients. In recent years, there has been a significant increase in the frequency of invasive fungal infections with the increase in patients with immunodeficiency. The use of [....] » Read More
Biocompatibility and non-toxicity of endodontic materials play an important role in the success of the treatment of pulp and periapical tissues. Due to the toxic effects of most of the sealers used in root canal filling, delay in wound healing, inflammation, and bone resorption a [....] » Read More
Alginate beads may be employed as controlled release carriers, and self-emulsion enhances solubility and bioavailability for γ-oryzanol/algae oil. Self-emulsified alginate beads (SEABs) were made using various weight ratios of self-emulsion treatment (5, 10, 15, 20, and 30% [....] » Read More
The present study involves enhancement of dissolution rate of 60 mg raloxifene HCl (RLX) immediate release tablets prepared by solid dispersion technique. Melting method was adopted for solid-dispersion technique. Melting point, FTIR and UV-spectrophotometric scanning were perfor [....] » Read More
Ethnomedicinally, the roots of Thalictrum foliolosum DC has long been used traditionally in opthalmia as a collyrium, improves eye-vision, relieves toothache, in diarrhea, cure piles to god extent, nail troubles, and also in discoloration of the skin. Because of lack of proper id [....] » Read More
Oral lichen planus is a chronic inflammatory illness that affects the mouth's mucous membrane. It appears as white lacy patches, if not diagnosed early, can progress to mouth cancer. Oral treatment is commonly delivered in the form of pills, capsules, tablets, and syrups. The [....] » Read More
Title : Resveratrol derivatives a new tool for osteogenic induction in the treatment of peri implantitis
Barbara De Filippis, University “G. d’Annunzio, Italy
Dental implants offer a reliable therapeutic option for tooth replacement therapy. However, the early and late failures are still a major concern of clinicians. Peri-implant tissues contribute to ensuring healthy conditions, stable osseointegration, and long-term survival because [....] » Read More
Title : miR-29b inhibition in triple negative cells target apoptosis and autophagy related mechanisms
Cornelia Braicu, Iuliu Haţieganu University of Medicine and Pharmacy, Romania
Introduction: The lack of receptors in triple-negative breast cancer (TNBC) restricts therapeutic alternatives options that can be used for clinical management. microRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate gene expression. miR-29b w [....] » Read More
Title : Mucoadhesive microcapsule: A novel approach for controlling & sustained drug delivery!
Subas Chandra Dinda, Teerthanker Mahaveer University, India
Statement of the Problem: Problems associated with poor bioavailability through oral route and administration difficulties through injectable routes promoted the impetus for exploring alternative routes for the delivery of such drugs. Application of dosage forms through mucosal s [....] » Read More
Title : Innate Immune memory based therapeutics in the resolution of inflammation
Liwu Li, Virginia Polytechnic Institute and State University, United States
Emerging studies suggest a novel role of innate immune memory during the pathogenesis and treatment of diverse inflammatory diseases. However, the fundamental principles that underlie the generation of innate immune memory are not well understood, thus hindering the effective dev [....] » Read More
Title : Targeting breast cancer through prodrug activation by cytochrome P450 1A1
Sebastien Fortin, Laval University, Canada
Human cytochromes P450 (CYPs) constitute a large superfamily of monooxygenase enzymes that catalyze over 40 different redox reactions. They are ubiquitous and are the main enzymes involved in drug biotransformation. CYPs also metabolize a considerable number of structurally diffe [....] » Read More
Title : Introducing Novel Hybridization Technique for Solubility Enhancement of Bosentan Formulation
Chetna Dipak Modi, Anand Pharmacy College, India
Bosentan is one of 40% NCEs developed in Pharma-Industry which are practically insoluble in water & choice of drug for pulmonary arterial hypertension. Due to poor solubility in aqueous media, treatment leads to frequent dosing & increasing cost of therapy subsequently. O [....] » Read More
Title : Formulation Development and Characterization of Novel Nano formulation to Enhance Bioavailability by Using Quality by Design Approach
Neha Bajwa, Maharaja Ranjit Singh Punjab Technical University, India
Background : Malaria is endemic in over 90 countries in which 2400 million people live (WHO, 2017). With the emergence of widespread chloroquine resistance and worldwide scarcity of quininine, search for newer antimalarial drugs has become imperative (Chadda et al., 2011). [....] » Read More
Title : Solid dispersion approach for solubility enhancement of Arteether employing hydrophilic carriers
Shagun Katoch, Maharaja Ranjit Singh Punjab Technical University, India
Arteether (AE), an ethyl ether derivative of dihydroartemisinin, is one of the most extensively utilized medicaments in treating drug-resistant malaria globally. It is a BCS class II drug with low solubility (≅17μg/mL), limited dissolution rate, and oral bioavailabil [....] » Read More
Title : Quality by Design based Development and Characterization of Patient Compliant Dosage form for Pediatrics
Srishti Naryal, Maharaja Ranjit Singh Punjab Technical University, India
The development of pediatric dosage forms can be challenging due to administration route, strength, and toxicity issues. In addition, children do not well receive the conventional pediatric formulations for various reasons, including choking due to larger size, vomiting due [....] » Read More
Title : Development, Optimization, and Characterization of Golden Milk as Immunobooster in Covid-19 using Qbd Approach
Pallvi Saroch, Maharaja Ranjt Singh Punjab Technical University, India
In the wake of the COVID-19 outbreak, enhancing the body’s immunity plays an important role in maintaining optimum health. Turmeric in milk generally known as golden milk is recommended to consume for boosting immunity. In the present study, turmeric milk powder was prepare [....] » Read More
Title : Quality by Design approach based Development of Arteether loaded Solid Lipid Nanoparticles
Trisha Sharma, Maharaja Ranjt Singh Punjab Technical University, India
Malaria is a severe endemic disease that affects 5% of the population across the globe. In 2018, there were 198 million cases of malaria, which resulted in 5,84,000 fatalities. The majority of these instances (90%) occurred in children under the age [....] » Read More
Title : Development of Flavoured Oral Disintegrating Mini Tablets by Using Quality by Design Approach
Shipra Mahal, Maharaja Ranjt Singh Punjab Technical University, India
Designing a pediatric formulation is a challenge due to palatability, administration issues and also requires a thorough understanding of developmental physiological changes, specific dose requirements according to child's body surface area, age as well as toxi [....] » Read More
Title : Studies on formulation and evaluation of orally disintegrating tablets using musa acuminata as a natural disintegrant for paediatric use
Ashwini V Jadhav, Genba Sopanrao Moze College of Pharmacy, India
The aim of the present study was to optimize an orally disintegrating tablet of ibuprofen (~100mg) using Musa acuminata (dehydrated banana powder) as a natural super disintegrant. In this work dehydrated banana powder was used as pharmaceutical excipient because of natural [....] » Read More
Title : Nutraceuticals in the prevention and treatment of Covid-19
Richard Cheng, Cheng Integrative Health Center, United States
Over a short 2+ years of the Covid-19 pandemic, SARS-Cov-2 virus has undergone numerous mutations with several major global outbreaks such as the delta and omicron variants. Covid-19 is not over yet, monkeypox is now lurking at the corner. Global responses to Covid-19 include soc [....] » Read More
Title : Cost effectiveness of antineoplastic agents preparations for personalized cancer therapy in the UHC “Mother Theresa” Tirana
Florjana Rustemi, Albanian University, Albania
This study determines the cost effectiveness of personalized cancer therapy based on the reduction of costs for each treatment cycle for the drug Bortezomib using antineoplastic agents’ preparation in the bio-safety cabinet of the Hematology pharmacy of the UHC “Mothe [....] » Read More
Title : Novel Spiro Hybrids of 2-indolinone and Thiazolodinone Scaffolds as Cell Cycle Checkpoints’ Pathways Regulators with potential anticancer activity
Tarek Aboul Fadl, Assuit University, Egypt
In recent years, cell cycle and checkpoint pathways regulation are offering new therapeutic approaches against cancer. 2-Indolinone, is a well exploited scaffold in the anticancer domain. Accordingly and in continuation of our previous studies, the current work describes merged s [....] » Read More
Title : In Vitro And Ex-Vivo Evaluation Of Curcumin Loaded Olive Oil/Beeswax Oleogels
Ahmet Dogan Ergin, Trakya University/Faculty of Pharmacy, Turkey
Oleogels are organic gels that are prepared by adding an organogelator agent to a liquid oil that will gel it, turn into solid/semi-solid form at room temperature, mostly consisting of thermoreversible three-dimensional network structures. It is a newly developed technology in re [....] » Read More