6th Edition of Global Conference on

Pharmaceutics and Novel Drug Delivery Systems

June 13-14, 2022 | Online Event

PHARMACEUTICS 2022

Innate Immune memory based therapeutics in the resolution of inflammation

Speaker at Pharmaceutics and Novel Drug Delivery Systems 2022 - Liwu Li
Virginia Polytechnic Institute and State University, United States
Title : Innate Immune memory based therapeutics in the resolution of inflammation

Abstract:

Emerging studies suggest a novel role of innate immune memory during the pathogenesis and treatment of diverse inflammatory diseases. However, the fundamental principles that underlie the generation of innate immune memory are not well understood, thus hindering the effective development of innate-based therapeutics.  We have defined the signal-strength and history dependent memory adaptation of innate immune cells including monocytes and neutrophils in both murine and human systems.  Integrative single cell RNAseq and protein-based analyses reveal the existence of unique subsets of memory monocytes/neutrophils with divergent inflammatory and/or resolving natures.  Genetic studies reveal that TRAM-mediated signaling circuitry is required for the establishment of inflammatory and/or exhausted innate memory leukocytes, and that the deletion of TRAM can effectively reprogram innate immune cells into a novel resolving phenotype. Our pharmacological approach independently reveal that the application of 4-PBA can similarly reprogram resolving innate immune cells conducive for the treatment of both acute sepsis as well as chronic inflammatory atherosclerosis.  Taken together, our systems analyses reveal that resolving innate leukocytes have therapeutic potentials in restraining inflammation and promoting host defense.

Biography:

Dr. Liwu Li, is a professor of Inflammation/Immunology, the director of GBCB (Genetics, Biotechnology, and Computational Biology), at the Virginia Tech University, USA.  He obtained a PhD in biology at the University of Michigan in 1996, followed by post-doctoral training with Dr. Jack Dixon related to enzyme kinetics of key phosphatases till 1999.  He was a faculty at Wake Forest University for 6 years before relocating to Virginia Tech University. He served as the President of Inflammation Research Association, and published over 140 articles regarding innate immune memory and leukocyte therapeutics related to sepsis, atherosclerosis and cancer. 

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