Title : Resveratrol derivatives a new tool for osteogenic induction in the treatment of peri implantitis
Abstract:
Dental implants offer a reliable therapeutic option for tooth replacement therapy. However, the early and late failures are still a major concern of clinicians. Peri-implant tissues contribute to ensuring healthy conditions, stable osseointegration, and long-term survival because they prevent microbial invasion, and consequently peri-implantitis. Moreover, the fibroblasts, particularly rich in the gingival tissue, acts against bacterial invasion and the possible inflammation, which may involve bone tissue causing marginal bone resorption and soft tissue recession. The treatment of peri-implantitis involve the surface decontamination that could be performed with mechanical and chemical compounds; the regeneration of the lost tissues, soft and hard, still represent the most difficult goal to achieve. For this purpose, a molecule with both antimicrobial properties, and proliferative action on osteoblasts and endothelial cells, may offer a valuable approach to overcoming limits of other strategies.
Many natural polyphenols are involved in pathways that can cross-talk to other multiple transduction signals; they possess promising higher beneficial efficacy and safety, and represent an alternative to pharmaceuticals due to low immunogenicity and toxicity. These characteristics make phenolics a promising natural source to be employed in the development of plant-based therapeutics, with a wide application-use ranging from bone diseases to cancers and neurodegenerative disorders.
Resveratrol is a polyphenolic phytoalexin present in natural sources with a large range of beneficial physiological effects. It exhibits several biological activities as antioxidant, anti-inflammatory, and antibacterial.
Administration of RSV has been shown to inhibit alveolar bone loss and modulates many critical factors in gingival tissues, diminishes oxidative stress and pro-inflammatory cytokine production showing an anti-inflammatory effect by acting on key signals. In addition to the inhibitory action against osteoclasts, RSV may be a promoter of osteoblast proliferation improving oxidative stress and mitochondrial dysfunction.
On the activity of RSV derivatives on bone regeneration. Based on these premises, and to overpass the unfavorable bioavailability of RSV, we synthesized and studied a set of sulfonamide derivatives of RSV containing the stilbene core of RSV bound by a sulfonamide bridge to a lipophilic portion, as a substituted aromatic ring, an alkyl chain or benzyl group or the bioisostere thiophene. We evaluated their cytocompatibility with human osteoblasts, human gingival fibroblasts, and endothelial cells of the human umbilical vein (Huvec) by proliferation and viability studies.
This work could reveal a potential synergistic action on the targets of these new compounds and may contribute to expand their biological applications in regenerative fields.
Many natural polyphenols are involved in pathways that can cross-talk to other multiple transduction signals; they possess promising higher beneficial efficacy and safety, and represent an alternative to pharmaceuticals due to low immunogenicity and toxicity. These characteristics make phenolics a promising natural source to be employed in the development of plant-based therapeutics, with a wide application-use ranging from bone diseases to cancers and neurodegenerative disorders.
Resveratrol is a polyphenolic phytoalexin present in natural sources with a large range of beneficial physiological effects. It exhibits several biological activities as antioxidant, anti-inflammatory, and antibacterial.
Administration of RSV has been shown to inhibit alveolar bone loss and modulates many critical factors in gingival tissues, diminishes oxidative stress and pro-inflammatory cytokine production showing an anti-inflammatory effect by acting on key signals. In addition to the inhibitory action against osteoclasts, RSV may be a promoter of osteoblast proliferation improving oxidative stress and mitochondrial dysfunction.
In the activity of RSV derivatives on bone regeneration. Based on these premises, and to overpass the unfavorable bioavailability of RSV, we synthesized and studied a set of sulfonamide derivatives of RSV containing the stilbene core of RSV bound by a sulfonamide bridge to a lipophilic portion, as a substituted aromatic ring, an alkyl chain or benzyl group or the bioisostere thiophene. We evaluated their cytocompatibility with human osteoblasts, human gingival fibroblasts, and endothelial cells of the human umbilical vein (Huvec) by proliferation and viability studies.
This work could reveal a potential synergistic action on the targets of these new compounds and may contribute to expand their biological applications in regenerative fields.
