Synthesis and in vitro study of antiproliferative heterocyclic scaffolds

Title : Synthesis and in vitro study of antiproliferative heterocyclic scaffolds

Abstract:

To discuss the reports on various antiproliferative Heterocyclic Scaffolds (APHSs) produced by different reaction protocol such as optimization conditions, importance of catalyst, routes for the diverse synthesis etc. The antiproliferative assay will be explore for all synthesized APHSs against the six human solid tumours cell lines. SAR of some potent Heterocyclic molecules and  ADMET prediction, the effect of P-glycoprotein on the antiproliferative activity will be discussed. Furthermore, How our method allows eco-friendly access to APHSs as potential anticancer drugs that will be highlight.

Biography:

Dr Hitendra Patel is a Professor of Chemistry at the Department of Chemistry of the Sardar Patel University, V. V. Nagar, Gujarat, India. He was an Elected Member of the Organic Division Council and was admitted as a Fellow of the Royal Society of Chemistry, London in 2020. He acts as Editor and Review Editor, Editorial board member in many international high repute journals. His research interests include the Development of Bioactive Heterocyclic Scaffolds via Multi-component reactions, with a focus on Green Chemistry approaches and Medicinal Chemistry, including synthesis of small molecules, virtual and biomolecular screening. He has published more than 32 research and review papers.