Effective drugs aim to target tissue damage, tumors, or drugs with low toxicity at the infection site. In the treatment of many disease conditions, targeted medication delivery has become more crucial in boosting the pharmacological effects of pharmaceuticals and lowering their deleterious repercussions. Despite the discovery of multiple surface markers and targeting techniques, only a few targeted drug delivery systems can achieve high targeting efficiency following intravenous injection. As a result of their improved therapeutic specificity and success in the treatment of the disease, cell-mediated drug-delivery targeting systems have gained a lot of interest. There are numerous potential biomedical applications for cell-based drug delivery systems, opening up fresh insights on the therapeutic potential of our cells. Intracellular delivery of various drugs, including DNA and drug carriers, can dramatically improve the efficacy of different treatment methods.