The severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus causes Coronavirus Disease 2019 (COVID-19), a novel disease. COVID-19 has created a global threat, resulting in large human mortality and serious economic losses, necessitating a greater understanding of the current situation and the development of sensible solutions to halt the virus's rapid spread. Drug repurposing screens are a helpful and successful means of determining prospective SARS-CoV-2 treatments. As a result, better therapeutic solutions are required. Multitarget medication combination therapy has been shown to be effective in the treatment of HIV, and it is likely to be a viable therapeutic option for COVID-19.